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Analysis using the Illumina Infinium Methylation EPIC BeadChip array on 19 DR-TLE patients and 10 non-epileptic controls revealed 32, 59, and 3,210 differentially methylated probes (DMPs) in the hippocampus, amygdala, and epileptogenic zone surrounding cortex (SCEZ), respectively (232)
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One major factor is heterogeneity in patient populations, as studies include diverse cohorts such as trauma patients, sepsis patients, ARDS patients, burn patients, and general ICU populations, each with varying degrees of oxidative stress and baseline selenium levels